RESUME
Atopic dermatitis (AD) is a chronic inflammatory
dermatosis characterized by intense itching. It is a multifactorial disease
that results from the interaction of genetic and environmental factors, defects
in barrier function, and a series of immunological factors. In addition, you can find more helpful resources at popbom AD mainly affects
childhood, but it can also persist or begin in adults. Characterized by severe
itching, morphology, and typical distribution of lesions, it has become
attractive to pediatric dermatologists, pediatricians, allergists, and immunologists. nanobiztech Its prevalence is increasing, and today two facts become relevant: the great
impact on the quality of life of young patients and their families and the
manifestation, which is the first manifestation of atopic syndrome. In addition, you can find more helpful resources at tockhop The
clinical lesions of AD usually involve elbows in the form of exudative or
lichenified eczema; there are many patients with atypical lesions or
morphology. We consider etiopathogenesis, diagnostic criteria, clinical,
differential diagnosis and treatment, focusing on the treatment of severe
asthma or refractoriness to traditional treatments, focusing on the latest globalmarketingbusiness advances in the study of its pathophysiology, as well as management through
therapeutic algorithms.
SUMMARY
Atopic dermatitis (AD) is a manifestation of a chronic
inflammatory skin disease that usually begins in early childhood. allinonetechs
It is characterized by severe pruritus, morphology and
distribution of lesions and is currently of interest to pediatric
dermatologists, pediatricians, allergists besides immunologists. Its prevalence
is increasing, and two evidences are currently relevant: an adverse effect on
the quality of life of patients and evidence that this is the first sign of
atopic syndrome.
Inconsistencies in treatment recommendations are crowding
out great advances in pathophysiology, just as the algorithmic management of AD
crowds out the art of treatment. leadmarketingbusiness
Definition
Atopic dermatitis (AD) is a chronic, recurrent
inflammatory process of the skin with intense itching. It usually appears in
early infancy and childhood, but can persist or begin into adulthood.
Genetic factors
70–80% of patients have a positive family history of
atopy. Genetic influence is complex, the maternal component being the most
important. A recent large-scale DNA microarray study showed that four genes involved
in epidermal differentiation, located on chromosome 1q21, show different levels
of expression in eczematous skin lesions compared to controls.
Determining the genetic pattern of AD is in itself a
difficult task, given the diverse phenotypes, as well as genetic and
immunological heterogeneities. It is known that it is common in the family,
although the agreement is incomplete; in single twins, the concordance
frequency reaches 77, and in dizygotic twins, 15%.
So far, two different approaches have been used to study
the genome; the first, which we could call "linkage", attempts to
find a link between a particular phenotype and a chromosomal region; the
second, which we could call "association", focuses on a particular
chromosome and genetic locus and attempts to link the polymorphism of that gene
with the clinical manifestation of AD.
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